Table 2.

Comparison of shapes between patients with bipolar disorder and healthy controls

Bundle	Df	Dim	Diagnosis		FA		Scanner		Age		Sex
			F1	p value	F1	p value	F2	p value	F1	p value	F1	p value
Left AF	187	1	1.4	0.23	14.2	< 0.001*	2.1	0.13	5.1	0.026	0.8	0.78
		2	15.1	< 0.001*	24.5	< 0.001*	1.9	0.16	3.5	0.06	0.3	0.61
Right AF	176	1	3.2	0.07	11.1	0.001†	0.6	0.54	7.8	0.006†	0.7	0.39
		2	0.1	0.84	1.3	0.24	4.4	0.014	0	0.96	0.7	0.39
Left CG	187	1	0.4	0.54	48.6	< 0.001*	0.73	0.48	0	0.89	0.39	0.53
		2	4.99	0.027†	0	0.87	2.5	0.08	0.8	0.37	0.3	0.56
Right CG	187	1	0.	0.91	32.4	< 0.001*	8.3	< 0.001†	0	0.99	0.8	0.91
		2	3.5	0.06	1.5	0.22	10.7	< 0.001*	0.7	0.40	0	0.87
Left UN	187	1	4.4	0.036†	30.3	< 0.001*	26.1	< 0.001*	4.9	0.029†	2.8	0.10
		2	1.	0.31	0.5	0.48	7.7	< 0.001†	3.0	0.08	1.7	0.20
Right UN	187	1	2.	0.16	3.0	0.08	39.7	< 0.001*	10.2	0.002†	0.3	0.57
		2	2.9	0.09	2.8	0.09	36.1	< 0.001*	0	0.97	0.4	0.51

AF = arcuate fasciculus; CG = cingulum; Df = degrees of freedom; Dim = dimension; FA = fractional anisotropy; UN = uncinate fasciculus.

^*Significant effect after Bonferroni correction for multiple tests (p < 4 × 10⁻⁴)

^†Trend toward significance after Bonferroni correction for multiple tests (4 × 10⁻⁴ < p < 0.05).