Fig. 7.

Calcium/calmodulin-dependent serine protein kinase (CASK) T740A mice show an extinction deficit in conditioned taste aversion (CTA). (A) CTA paradigm. (B) Amounts of water and sucrose consumed at training day −1 (D −1) and on training day (D0). Both mutant and wild-type (WT) mice preferred sucrose before the assay. (C) CASK T740A mice do not extinguish old memories in a CTA test. The injection dosage of LiCl and NaCl is 0.15 M. (D) Dosage effect of LiCl in CTA. Mice were treated with 0.1 M or 0.15 M LiCl. (E, F) Mutant and WT mice exhibit no differences in nonconditioned tests and forgetting. Sample sizes are indicated. *p < 0.05; **p < 0.01.