Fig. 4.

Mean values of plaque load in the cerebral cortex and hippocampus taken from 40 μm-thick coronal sections stained to detect endogenous Aβ by immunohistochemistry. (A) Statistical evaluation revealed a significant decrease in plaque load in the cortex of transgenic mice treated with ASS234 compared with transgenic vehicle-treated mice (unpaired t test, p = 0.002). (B) A trend toward a reduction in plaque load was observed in the hippocampus. Data are represented as means ± standard errors of the mean.