Table 5.
Factors associated with CSS and OS among patients with synchronous colorectal cancer liver metastases treated with simultaneous resection in Ontario between 2002 and 2009 (n = 100*)
| Covariate | Multivariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| 5-year CSS | HR (95%CI) | p value | 5-year OS | HR (95%CI) | p value | |
| Patient-related | ||||||
|
| ||||||
| Age, yr | 0.035 | 0.005 | ||||
|
| ||||||
| < 65 | 55% | Ref | 50% | Ref | ||
|
| ||||||
| 65–74 | 21% | 2.18 (1.04–4.56) | 28% | 1.95 (1.04–3.64) | ||
|
| ||||||
| ≥ 75 | 0% | 2.79 (1.12–6.96) | 0% | 3.37 (1.56–7.29) | ||
|
| ||||||
| Charlson Comorbidity Index score | 0.33 | 0.49 | ||||
|
| ||||||
| 0 | 41% | Ref | 39% | Ref | ||
|
| ||||||
| ≥ 1 | 0% | 1.60 (0.63–4.08) | 0% | 1.31 (0.60–2.86) | ||
|
| ||||||
| Disease-related | ||||||
|
| ||||||
| Mean no. of lesions | 0.58 | 0.26 | ||||
|
| ||||||
| 1 | 40% | Ref | 40% | Ref | ||
|
| ||||||
| > 1 | 36% | 1.23 (0.59–2.54) | 29% | 1.38 (0.79–2.42) | ||
|
| ||||||
| Mean size largest lesion, cm | 0.13 | 0.15 | ||||
|
| ||||||
| < 5 | 36% | Ref | 36% | Ref | ||
|
| ||||||
| ≥ 5 | 37% | 2.03 (0.81–5.10) | 29% | 1.74 (0.82–3.67) | ||
|
| ||||||
| Treatment-related | ||||||
|
| ||||||
| Extent of surgical resection | 0.038 | 0.027 | ||||
|
| ||||||
| Minor (< 3 segments) | 32% | Ref | 30% | Ref | ||
|
| ||||||
| Major ( > 3 segments) | 57% | 0.31 (0.10–0.94) | 57% | 0.38 (0.16–0.90) | ||
CI = confidence interval; CSS = cancer-specific survival; HR = hazard ratio; OS = overall survival.
*
Seven cases excluded from analysis owing to unavailable data (number lesions, lesion size, extent of surgical resection).