Figure 2. Longitudinal changes in urinary extracellular domain of p75 (p75^ECD) in amyotrophic lateral sclerosis (ALS) as disease progresses.

(A) Individual patient urinary p75^ECD trajectories increase since time of diagnosis at an average rate of 0.19 ng/mg creatinine per month (95% confidence interval [CI] 0.15–0.24). (B) p75^ECD trajectories also increase since time from symptom onset (0.18 ng/mg, 95% CI 0.13–0.22), and (C) time since the initial evaluation and sample collection (i.e., baseline) (0.20 ng/mg, 95% CI 0.15–0.25). Total 31 patients with ALS, each sampled at least twice.