Table 3.

Comparison of subcortical volumes and white matter regions in 22q11DS participants with ASD (22q11DS-ASD+) to 22q11 DS participants without ASD (22q11DS-ASD−), and healthy controls. Cells highlighted in yellow indicate a statistically significant difference (p<.05) between22q11DS-ASD+ vs. 22q11DS-ASD− in the pairwise comparisons. Cells highlighted in gray were not examined in post-hoc analyses because the significance in the overall F-test (ANCOVA) was q > .05.

Region of Interest	Hemi- sphere	F	FDR q- value	Effect Size	↑ or ↓ in 22q11DS -ASD+ vs. 22q11DS -ASD-	↑ or ↓ in 22q11DS -ASD+ vs. CTL	↑ or ↓ in 22q11DS -ASD- VS. CTL
Cerebellum (white matter)	L	26.1	0.000000009	0.32		↓	↓
	R	26.3	0.000000009	0.33		↓	↓
Cerebellum (cortex)	L	18.0	0.000002	0.25		↓	↓
	R	17.6	0.000002	0.24		↓	↓
Caudate	L	4.8	0.02	0.08		↑	↑
	R	7.2	0.003	0.11		↑	↑
Putamen	L	2.4	0.13	0.04
	R	5.6	0.01	0.09		↓	↓
Hippocampus	L	4.6	0.02	0.08		↓
	R	12.3	0.0001	0.18		↓	↓
Amygdala	L	4.7	0.02	0.08		↓	↓
	R	7.0	0.003	0.11	↓	↓
Nucleus accumbens area	L	2.7	0.11	0.05
	R	11.4	0.0002	0.17		↑	↑
Ventral diencephalon	L	5.5	0.01	0.09		↓	↓
	R	3.9	0.04	0.07		↓
Thalamus	L	0.7	0.56	0.01
	R	0.9	0.45	0.01
Pallidum	L	2.7	0.11	0.05
	R	3.2	0.06	0.06
Corpus callosum (posterior)	N/A	3.1	0.07	0.05
Corpus callosum (mid- posterior)	N/A	0.3	0.8	0.01
Corpus callosum (central)	N/A	1.1	0.4	0.02
Corpus callosum (mid- anterior)	N/A	0.3	0.7	0.01
Corpus callosum (anterior)	N/A	11.2	0.0002			↑	↑

↓ or ↑ indicates measures that showed a statistical significance in the results (p-values <.05).