Table 4.

Comparison of cortical thickness and surface area in 22q11DS-ASD+, 22q11DS-ASD− and typically developing controls (CTL). Cells highlighted in yellow indicate a statistically significant difference (p<.05) between 22q11DS-ASD+ vs. 22q11 DS-ASD- in the pairwise comparisons. Cells highlighted in gray were not examined in post-hoc analyses because the significance in the overall F-test (ANCOVA) was q > .05.

		Cortical Thickness						Surface Area
Region of Interest	Hemisphere	F	FDR q-value	Effect size	↑ or ↓ in 22q11DS-ASD+ vs. 22q11DS-ASD−	↑ or ↓ in 22q11DS-ASD+ vs. CTL	↑ or ↓ in 22q11DS-ASD− vs. CTL	F	FDR q-value	Effect size	↑ or ↓ in 22q11DS-ASD+ vs. 22q11DS-ASD−	↑ or ↓ in 22q11DS-ASD+ vs. CTL	↑ or ↓ in 22q11DS-ASD− vs. CTL
Banks of Superior Temporal Sulcus	L	0.5	0.7	0.009				3.7	0.05	0.06
	R	1.5	0.3	0.03				11.4	0.0002	0.17		↓	↓
Caudal Anterior Cingulate	L	4.4	0.02	0.08		↓		17.9	0.000001	0.25		↓	↓
	R	3.5	0.06	0.06				10.0	0.0004	0.16		↓	↓
Caudal Middle Frontal	L	9.1	0.0007	0.15		↑	↑	0.6	0.6	0.01
	R	5.8	0.007	0.1		↑	↑	0.04	1.0	0.001
Cuneus	L	4.5	0.02	0.08		↑	↑	44.3	1.3E-12	0.45		↓	↓
	R	2.4	0.1	0.04				38.8	1.4E-11	0.42		↓	↓
Entorhinal	L	0.9	0.5	0.02				2.6	0.1	0.05
	R	2.2	0.2	0.04				1.3	0.3	0.02
Fusiform	L	0.4	0.7	0.007				16.1	0.000005	0.23		↓	↓
	R	2.9	0.09	0.05				18.2	0.000002	0.25		↓	↓
Inferior Parietal	L	3.7	0.05	0.06				3.4	0.06	0.06		↓	↓
	R	9.3	0.0007	0.15		↑	↑	3.8	0.009	0.10		↓	↓
Inferior Temporal	L	0.6	0.6	0.01				29.8	1.5E-09	0.36		↓	↓
	R	2.0	0.2	0.04				13.0	0.00005	0.19		↓	↓
Isthmus Cingulate	L	0.6	0.6	0.01				0.8	0.5	0.01
	R	0.6	0.6	0.01				0.2	0.9	0.003
Lateral Occipital	L	1.2	0.4	0.02				10.8	0.0002	0.17		↓	↓
	R	1.8	0.2	0.03				7.3	0.003	0.12		↓	↓
Lateral Orbitofrontal	L	5.8	0.009	0.1		↑	↑	0.9	0.5	0.02
	R	5.1	0.02	0.09		↑		1.0	0.4	0.02
Lingual	L	5.9	0.007	0.1			↑	23.9	3.5E-08	0.31		↓	↓
	R	7.7	0.003	0.13		↑	↑	30.0	1.5E-09	0.36		↓	↓
Medial Orbitofrontal	L	4.6	0.02	0.08			↑	2.7	0.1	0.05
	R	10.8	0.0002	0.17		↑	↑	0.6	0.6	0.01
Middle Temporal	L	1.3	0.4	0.02				10.5	0.0003	0.16		↓	↓
	R	4.8	0.02	0.08		↑	↑	6.8	0.005	0.11		↓	↓
Parahippocampal	L	11.6	0.0002	0.18	↓	↓		1.8	0.2	0.03
	R	8.3	0.002	0.13	↓	↓	↓	3.7	0.05	0.06
Paracentral	L	10.0	0.0004	0.16		↑	↑	4.6	0.02	0.08		↓	↓
	R	8.8	0.001	0.14		↑	↑	3.8	0.05	0.07
Pars Opercularis	L	15.4	0.000007	0.22		↑	↑	0.4	0.7	0.007
	R	5.9	0.009	0.10		↑	↑	0.8	0.5	0.01
Pars Orbitalis	L	5.3	0.01	0.09		↑	↑	0.8	0.5	0.02
	R	2.0	0.2	0.04				0.1	0.9	0.002
Pars Triangularis	L	17.6	0.000002	0.24		↑	↑	3.5	0.05	0.06
	R	2.7	0.1	0.05				6.6	0.005	0.11		↓	↓
Pericalcarine	L	2.1	0.2	0.04				20.6	3.2E-07	0.28		↓	↓
	R	6.7	0.005	0.11	↓		↑	22.1	1.2E-07	0.29		↓	↓
Postcentral	L	8.3	0.001	0.133		↑	↑	8.0	0.003	0.13		↓	↓
	R	5.4	0.01	0.09		↑	↑	15.7	0.000007	0. 22		↓	↓
Posterior Cingulate	L	1.0	0.5	0.02				2.5	0.1	0.04
	R	1.9	0.2	0.03				4.2	0.04	0.07		↓	↓
Precentral	L	4.9	0.02	0.08		↑	↑	1.1	0.4	0.02
	R	8.0	0.003	0.13		↑	↑	0.9	0.5	0.02
Precuneus	L	3.7	0.05	0.06				24.2	3.1E-08	0.23		↓	↓
	R	9.0	0.0007	0.14	↓		↑	16.6	3.9E-06	0.23		↓	↓
Rostral Anterior Cingulate	L	1.6	0.3	0.03				10.1	0.0004	0.16		↓	↓
	R	1.9	0.2	0.03				8.7	0.001	0.14		↓	↓
Rostral Middle Frontal	L	14.0	0.00002	0.21		↑	↑	18.6	1.3E-06	0.25		↓	↓
	R	16.0	0.000005	0.23		↑	↑	27.3	6.3E-09	0.33		↓	↓
Superior Frontal	L	7.8	0.003	0.13	↓		↑	4.2	0.04	0.07		↓	↓
	R	6.1	0.005	0.10			↑	2.4	0.1	0.04
Superior Parietal	L	2.1	0.2	0.04				33.2	2.8E-10	0.38		↓	↓
	R	8.0	0.003	0.13		↑	↑	26.5	9.1E-09	0.33		↓	↓
Superior Temporal	L	3.6	0.05	0.06				0.7	0.6	0.01
	R	0.2	0.9	0.003				7.5	0.003	0.12		↓	↓
Supram arginal	L	10.9	0.0002	0.17		↑	↑	2.4	0.1	0.04
	R	11.8	0.0001	0.18		↑	↑	1.4	0.3	0.02
Frontal Pole	L	7.3	0.003	0.12		↑	↑	1.0	0.5	0.02
	R	0.6	0.6	0.01				0.3	0.7	0.006
Temporal Pole	L	5.1	0.02	0.09		↑	↑	9.3	0.0007	0.15		↓	↓
	R	0.4	0.7	0.008				5.9	0.009	0.10		↓	↓
Transverse Temporal	L	0.1	0.9	0.002				2.1	0.2	0.04
	R	1.2	0.4	0.02				3.0	0.08	0.05
Insula	L	10.5	0.0003	0.16		↑	↑	3.7	0.05	0.06
	R	8.2	0.001	0.13		↑	↑	3.8	0.05	0.07

↓ or ↑ indicates measures that showed a statistical significance in the results (p-values <.05).