Table 2.
ORF [Glycoprotein] |
Mutation | Phenotype | Reference | ||
---|---|---|---|---|---|
Cell culture | Skin | DRG | |||
ORFS/L | ΔTMD | WT in MeWo | - | - | [21] |
ORF5[gK] | ΔORF5 | Lethal | N/A | N/A | [17, 20] |
ΔNgK | Lethal | N/A | N/A | ||
ΔCgK | Lethal | N/A | N/A | ||
ΔCgK5251 | Lethal | N/A | N/A | ||
ORF9A[gN] | ΔgNA | Lethal | N/A | N/A | [20] |
ORF14[gC] | ΔgC | WT | Reduced | N/A | [20] |
ORF14stop | WT | - | - | [64] | |
ORF31[gB] | ΔgB | Lethal | N/A | N/A | [20] |
W180G | Lethal | N/A | N/A | [28] | |
Y185G | Lethal | N/A | N/A | ||
491GSGG494 | WT | Reduced | - | ||
491ΔRSRR494 | WT | Reduced | - | ||
Δ36 (gB-36) | Hyperfusion | - | - | [80] | |
Y881F | Hyperfusion | Reduced | - | [13] | |
Y920F | WT | WT | - | ||
Y881/920F | Hyperfusion | Reduced | - | ||
ORF37[gH] | ΔgH | Lethal | N/A | N/A | [19, 20] |
αX | WT | Reduced | - | [19] | |
S42A | WT | WT | - | ||
N45A | WT | WT | - | ||
S47A | WT | Reduced | - | ||
S47T | WT | WT | - | ||
T127A | WT | WT | - | ||
C327A | WT | WT | - | ||
T351A | WT | WT | - | ||
C647A | Small Plaque | Reduced | - | ||
S694F | - | - | - | ||
C703A | Small Plaque | Reduced | - | ||
S694F/C724A | - | - | - | ||
C727A | Small Plaque | Reduced | - | ||
S694F/C727A | WT | Reduced | - | ||
T751A | Small Plaque | WT | - | ||
α8 | Lethal | N/A | N/A | ||
α9 | Lethal | N/A | N/A | ||
α12 | Lethal | N/A | N/A | ||
α14 | Lethal | N/A | N/A | ||
C540A | Lethal | N/A | N/A | ||
C575A | Lethal | N/A | N/A | ||
C724A | Lethal | N/A | N/A | ||
781FPNG784 | Lethal | N/A | N/A | ||
ORF37[gH] | gH-TL (834 stop) | Hyperfusion | Reduced | - | [81] |
Δ834–841 | Hyperfusion | Reduced | - | ||
834StopV5 | Hyperfusion | - | - | ||
gH-V5 | WT | WT | - | ||
Y835A | WT | WT | - | ||
Y835F | WT | WT | - | ||
ORF39 | ΔORF39 | Lethal | N/A | N/A | [20] |
ORF50[gM] | ΔgMB | Lethal | N/A | N/A | [20] |
gMim[V42P,G301M] | Small plaque | - | - | [18] | |
ORF50AS(−) | WT | - | - | ||
ORF60[gL] | ΔgL | Lethal | N/A | N/A | [20] |
ORF67[gI] | ΔgI | Small Plaque | Reduced | Reduced | [16, 20, 25, 31] |
Δ37–167 | Small Plaque | - | - | [29] | |
Δ105–125 | Small Plaque | Reduced | - | ||
C83A | WT | - | - | ||
C95A | Small Plaque | Reduced | - | ||
C106A | WT | WT | - | ||
C200A | WT | - | - | ||
N116A | WT | WT | - | ||
ORF68[gE] | ΔgE | Lethal | N/A | N/A | [16, 20] |
Insertion G16 | Lethal | N/A | N/A | [22] | |
Insertion P27 | Reduced | Reduced | - | ||
Insertion Y51 | WT | WT | - | ||
Insertion G90 | WT | - | - | ||
Insertion I146 | WT | - | - | ||
Insertion P187 | WT | - | - | ||
S31A | WT | Reduced | - | ||
S49A | WT | WT | - | ||
ΔP27-Y51 | WT | - | - | ||
ΔY51-P187 | Reduced | Not recovered | - | ||
ΔP27–P187 | Lethal | N/A | N/A | ||
ΔCys208–236 | Reduced in HELFs | Reduced | Delayed | [23, 32] | |
ΔP27-G90 | Small Plaque | Reduced | - | [24] | |
ΔY51-G90 | Small Plaque | WT | - | ||
Δ32–71 | Small Plaque | - | - | [84] | |
Δ163–208 | Lethal | N/A | N/A | ||
Y582G (YAGL) | Lethal | N/A | N/A | [26] | |
gEΔcyt | Lethal | N/A | N/A | ||
Y569A (AYRV) | WT | WT | WT | [26, 32] | |
593AEAADA598 | Increased | Increased | WT |
Also deletes a portion of ORF8.
WT – Wild type, not different from parental virus. N/A – Not applicable. Not tested (−)
Also deletes a portion of ORF51.
WT – Wild type, not different from parental virus. N/A – Not applicable. Not tested (−)