Video 5. Simulated time course of receptor activation upon clustering in a heterogeneous membrane without the positive feedback loop accomplished through receptor bound kinases.
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DOI: 10.7554/eLife.19891.033
Simulations are conducted as described in Methods. The positions of receptors (circles), kinases (green squares), and phosphatases (magenta triangles) are shown at 1 ms intervals (representing 1000 simulation updates). Inactive receptors are shown in blue and activated (phosphorylated) receptors are shown in red. Symbols are drawn larger than the pixels that they represent for clarity. The receptor field is turned on at time = 0 to induce receptor clustering. The time trace shown at the bottom is redrawn from Figure 4b.