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The NTCP model for late tissue predicts the double-trouble (according to higher fraction size) and triple-trouble (according to high total dose) effects for hotspots >10% of PD (blue dotted line) and for hotspots >20% of PD (pink dotted line). *The formula refers to Lyman’s model18 but the original data from this study has been applied.
Abbreviations: NTCP, normal tissue complication probability; PD, prescribed dose; PTV, planning target volume; BED, biologically effective dose.
