Table 2.
Experimental runs and results of resveratrol micelles based on CCD
| Formulae | RES (mg/mL) | P127/TPGS | EE% | DL% | PS (nm) |
|---|---|---|---|---|---|
| M1 | 0.625 | 7:5 | 97.90 | 8.96 | 20.01 |
| 0.625 | 7:5 | 95.41 | 8.72 | 20.37 | |
| 0.625 | 7:5 | 97.61 | 9.08 | 21.38 | |
| 0.625 | 7:5 | 98.65 | 9.01 | 19.90 | |
| M2 | 1 | 2:5 | 72.88 | 6.64 | 24.24 |
| M3 | 0.625 | 2:5 | 92.27 | 8.40 | 24.97 |
| M4 | 0.25 | 2:5 | 68.15 | 6.36 | 24.35 |
| M5 | 1 | 12:5 | 98.72 | 9.04 | 20.37 |
| M6 | 1 | 7:5 | 99.92 | 9.22 | 20.61 |
| M7 | 0.625 | 12:5 | 87.03 | 7.91 | 21.12 |
| M8 | 0.25 | 12:5 | 99.82 | 9.18 | 21.44 |
| M9 | 0.25 | 7:5 | 98.96 | 9.32 | 21.09 |
Abbreviations: CCD, central composite design; RES, reticuloendothelial system; P127, Pluronic 127; TPGS, D-α-tocopheryl polyethylene glycol 1000 succinate; EE, entrapment efficiency; DL, drug loading; PS, particle size.