Table 3.
Pharmacokinetic parameters of resveratrol micelles and the reference after i.v. administration (n=5)
| Parameter | Micelles | Solutions |
|---|---|---|
| AUC0→∞ (mg/L·h) | 4,683.46±351.26* | 1,716.30±310.22 |
| AUMC0→∞ | 5,739.42±278.34* | 763.51±262.71 |
| CL (L/h/kg) | 0.005 | 0.013 |
| MRT (h) | 1.23±0.07 | 0.42±0.08 |
Notes: Statistical significance compared with reference.
*
P<0.05. Data are represented as the mean ± SD.
Abbreviations: i.v., intravenous; AUC0→∞, area under the plasma concentration–time curve from zero to infinity; AUMC0→∞, area under the plasma concentration versus times curve (zero moment) and the first moment curve; CL, clearance; MRT, mean residence time; SD, standard deviation.