Table 2.
Clinical characteristics and treatment history among migraineurs with or without N/V
| Migraine characteristics/treatment | Migraineurs
|
*p-value | ||
|---|---|---|---|---|
| Total N=7,855 | With N/V (n=4,528) | Without N/V (n=3,327) | ||
| Migraine Symptoms, n (%) | ||||
| Aura | 1,940 (24.7) | 1,346 (29.7) | 594 (17.9) | <0.001 |
| Moderate to severe pain | 6,163 (78.5) | 3,908 (86.3) | 2,255 (67.8) | <0.001 |
| Nausea and/or vomiting | 4,528 (57.6) | 4,528 (100.0) | 0 (0.0) | <0.001 |
| Pulsating, throbbing, or pounding pain | 5,420 (69.0) | 3,566 (78.8) | 1,854 (55.7) | <0.001 |
| Pain is worse on one side of your head or occurs on one side of your head only | 4,146 (52.8) | 2,732 (60.3) | 1,414 (42.5) | <0.001 |
| Pain is made worse by routine activities such as walking or climbing stairs | 3,167 (40.3) | 2,330 (51.5) | 837 (25.2) | <0.001 |
| Bothered by or unusually sensitive to light | 5,620 (71.5) | 3,818 (84.3) | 1,802 (54.2) | <0.001 |
| Bothered by or unusually sensitive to sound | 4,567 (58.1) | 3,270 (72.2) | 1,297 (39.0) | <0.001 |
| See spots, flashing lights, or heat waves before or during the migraine | 3,050 (38.8) | 2,104 (46.5) | 946 (28.4) | <0.001 |
| Lasts for at least 4 hours but not more than 72 hours if untreated | 4,146 (52.8) | 2,902 (64.1) | 1,244 (37.4) | <0.001 |
| Severity of migraines, n (%) | ||||
| Mild | 1,255 (15.6) | 404 (8.9) | 821 (24.7) | <0.001 |
| Moderate | 3,974 (50.6) | 2,131 (47.1) | 1,843 (55.4) | |
| Severe | 2,656 (33.8) | 1,993 (44.0) | 663 (19.9) | |
| Preventative migraine treatments, n (%) | ||||
| Botox (botulinum toxin type a) | 83 (1.1) | 47 (1.0) | 36 (1.1) | 0.850 |
| Depakote (valproate semisodium) | 56 (0.7) | 27 (0.6) | 29 (0.9) | 0.152 |
| DepakoteER (divalproex sodium) | 35 (0.4) | 16 (0.4) | 19 (0.6) | 0.152 |
| Inderal (propranolol) | 102 (1.3) | 72 (1.6) | 30 (0.9) | 0.008 |
| Neurontin (gabapentin) | 181 (2.3) | 102 (2.3) | 79 (2.4) | 0.722 |
| Topamax (topiramate) | 512 (6.5) | 329 (7.3) | 183 (5.5) | 0.002 |
| Acute migraine treatments | ||||
| Alsuma (sumatriptan succinate) | 55 (0.7) | 20 (0.4) | 35 (1.1) | 0.001 |
| Amerge (naratriptan) | 40 (0.5) | 26 (0.6) | 14 (0.4) | 0.345 |
| Axert (almotriptan) | 44 (0.6) | 23 (0.5) | 21 (0.6) | 0.470 |
| Cambia (diclofenac potassium) | 47 (0.6) | 15 (0.3) | 32 (1.0) | <0.001 |
| Fioricet (butalbital/acetaminophen/caffeine) | 344 (4.4) | 234 (5.2) | 110 (3.3) | <0.001 |
| Fiorinal (aspirin/butalbital/caffeine) | 141 (1.8) | 76 (1.7) | 65 (2.0) | 0.364 |
| Frova (frovatriptan) | 63 (0.8) | 35 (0.8) | 28 (0.8) | 0.736 |
| ImitrexInjection (sumatriptan) | 130 (1.7) | 106 (2.3) | 24 (0.7) | <0.001 |
| ImitrexTablets (sumatriptan) | 729 (9.3) | 507 (11.2) | 222 (6.7) | <0.001 |
| ImitrexNasalSpray (sumatriptan) | 72 (0.9) | 47 (1.0) | 25 (0.8) | 0.188 |
| Midrin (acetaminophen/isometheptene/dichloralphenazone) | 207 (2.6) | 105 (2.3) | 102 (3.1) | 0.041 |
| Maxalt (rizatriptan) | 378 (4.8) | 247 (5.5) | 131 (3.9) | 0.002 |
| Relpax (eletriptan) | 176 (2.2) | 106 (2.3) | 70 (2.1) | 0.483 |
| Sumatriptan (sumatriptan) | 233 (3.0) | 163 (3.6) | 70 (2.1) | <0.001 |
| Treximet (sumatriptan/naproxen sodium) | 81 (1.0) | 45 (1.0) | 36 (1.1) | 0.702 |
| ZomigTablets (zolmitriptan) | 159 (2.0) | 98 (2.2) | 61 (1.8) | 0.304 |
| ZomigNasalSpray (zolmitriptan) | 24 (0.3) | 15 (0.3) | 9 (0.3) | 0.630 |
| Other | 761 (9.7) | 432 (9.5) | 329 (9.9) | 0.606 |
Note:
*
p-value represents comparison of with N/V vs without N/V. Values in bold represent significant pairwise differences at p<0.05 from tests of column proportions (z tests) for categorical variables.
Abbreviations: N/V, nausea/vomiting; BMI, body mass index; CCI, Charlson comorbidity index.