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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Nat Neurosci. 2017 Feb 13;20(4):540–549. doi: 10.1038/nn.4503

Figure 1. Cadherins are expressed in dopaminergic neurons and are essential for LTP in the VTA.

Figure 1

(a) VTA neurons co-immunostained for cadherins (green), dopamine transporter (DAT; magenta) and DAPI (blue). Arrowheads indicate neurons positive for both cadherin and DAT, asterisks indicate neurons which are positive for cadherin but not DAT. Scale bar = 10 μm. (b) Spike-timing-dependent LTP in the VTA was abolished by treatment with a peptide containing an HAV motif (His-Ala-Val) that disrupts N-cadherin extracellular interactions (### p<0.0001, significant interaction between peptide treatment and time, two-way RM ANOVA, F(78,624) = 4.037, *p< 0.05, Bonferroni’s test post hoc, n=8 cells/8 mice vehicle, 6 cells/6 mice HAV, 5 cells/5 mice HAV-S). Vehicle-only and scramble peptide (HAV-S) had no effect on LTP. Data shown as mean ± SEM.