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. 2017 Mar 13;127(4):1321–1337. doi: 10.1172/JCI89281

Figure 3. Cell-intrinsic moesin controls pTregs but is dispensable for tTreg generation.

Figure 3

(A) Immunoblot of moesin knockout (KO or Msn KO) in multiple organs of mice. (B) Representative enlarged spleen size and increased cell number as observed in Msn KO mice. (C–E) Reconstituted 1:1 mix of WT (CD45.1, black) and Msn KO (CD45.2, red) bone marrow chimeric mice. Flow cytometry analysis of pTregs (FOXP3+Helioslo) in the large intestine (C), spleen (D), and thymus (E) of mice reconstituted for 8–10 weeks. Data are reported as the mean ± SEM (B–E). **P < 0.01, ***P < 0.001 by Student’s t test. n = 6 per group (B–E).