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. 2017 Mar 13;127(4):1505–1516. doi: 10.1172/JCI88574

Figure 8. SIRT2 is decreased with iron overload in human liver.

Figure 8

(A) SIRT2 levels in liver biopsies from human patients with various degrees of secondary iron overload. LIC was determined by MRI. A summary of the measurements is shown underneath the images. Scale bar: 100 μm. Bars in the summary graph represent the group mean. *P < 0.05, by ANOVA with Bonferroni’s correction for multiple comparisons. (B) Representative immunostaining showing SIRT2 expression in human liver tissue from infants with NH or from nondiseased control infants. Quantification of iron content measured by Prussian blue staining (top right) and SIRT2 levels by immunofluorescence intensity (bottom right) from NH patients (n = 3–5). Black scale bar: 100 μm; white scale bar: 50 μm. *P < 0.05, by Student’s t test. (C) Model of iron regulation by SIRT2 and NRF2. Data are presented as the mean ± SEM.