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. 2017 Mar 20;127(4):1574–1588. doi: 10.1172/JCI89535

Figure 4. Ccl19-Cre–mediated Dll1 and Dll4 inactivation preserves lymphocyte numbers and distribution in SLOs at steady state.

Figure 4

(A) Absolute numbers of CD4+ T cells, CD8+ T cells, and B cells in spleens and LNs of B6 littermate control TgCcl19-Cre– or TgCcl19-Cre+ Dll1Δ/Δ Dll4Δ/Δ mice at steady state (n = 5 mice/group). (B and C) CD62L and CD44 expression in CD4+ (B) and CD8+ (C) T cells from spleens and LNs of TgCcl19-Cre– or TgCcl19-Cre+ Dll1Δ/Δ Dll4Δ/Δ mice at steady state. (D) Abundance of Il7 transcripts (qRT-PCR) in sort-purified PDPN+CD31– fibroblastic stromal cells from TgCcl19-Cre– or TgCcl19-Cre+ Dll1Δ/Δ Dll4Δ/Δ mice (n = 5 mice/group). NS = P > 0.05, by unpaired, 2-tailed Student’s t test. Data are representative of at least 3 experiments; error bars indicate SD.