Skip to main content
. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Brain Behav Immun. 2017 Jan 19;62:137–150. doi: 10.1016/j.bbi.2017.01.012

Fig 6.

Fig 6

Post-LPS infusion sleep responses. WT mice but not NLRP3 KO mice had significantly enhanced NREM and reduced wakefulness (min/2 h) amounts post-LPS infusion compared to the vehicle (A). REM sleep amounts (min/2 h) were not significantly different post-LPS infusion for either genotypes (B), although reduced wakefulness post-LPS was observed in WT mice but not NLRP3 KO mice (C). NLRP3 KO mice also did not show the significant enhancements in NREM sleep δ power during the first 4 hours post-LPS infusion (ZT 12-16) as was found in WT mice (D, E, F). However, post-hoc analysis did not show significant differences at individual frequency bands. N = 7 per genotype. (*) indicates significant difference between baseline and treatment. (#) indicates significant difference between genotypes. The Bonferroni corrected α value was set at p < 0.03 for sleep states during recovery sleep and p < 0.0006 for EEG power frequency bands.