. Author manuscript; available in PMC: 2018 May 1.

Published in final edited form as: J Appl Toxicol. 2016 Oct 3;37(5):530–544. doi: 10.1002/jat.3387

Table 5.

Concentration of silver (μg Ag/g) in tissues following p.o. administration (10 mg/kg) of AgAc, 20 nm AgNP or 110 nm AgNP to pregnant rats.

Tissue	AgAc		20 nm AgNP		110 nm AgNP
Tissue	24 h	48 h	24 h	48 h	24 h	48 h
Liver	0.187±0.106	0.324±0.380	0.0592±0.0293	0.0380±0.0126	0.0205±0.0150	0.0170±0.00377
Blood	<LOQ^b	0.117±0.0168	0.124±0.0120	0.0646±0.00519	<LOQ	<LOQ
Spleen	0.0802±0.0648	0.104±0.0702	0.220±0.0329	<LOQ	0.172^a	<LOQ
Lungs	0.137±0.0239	0.177^a	0.965^a	<LOQ	<LOQ	<LOQ
Heart	0.0604^a	<LOQ	<LOQ	<LOQ	<LOQ	<LOQ
Kidney	0.461±0.506	0.147±0.0413	0.187±0.0545	0.0868±0.0136	0.104±0.0387	0.0795±0.0179
Brain	<LOQ	<LOQ	<LOQ	<LOQ	<LOQ	<LOQ
Stomach and Small Intestine	1.55±2.51	0.0726±0.0286	0.0657±0.0324	0.0307±0.0141	0.584±0.468	0.0193±0.00657
Cecum and Large Intestine	16.0±25.6	0.400±0.0248	3.76±2.24	0.884±0.750	3.02±1.04	0.901±0.449
Placenta	0.751±0.0249	0.919±0.271	0.518±0.0302	0.354±0.307	0.201±0.125	0.351±0.106
Fetus	0.0537±0.000831	0.0663±0.0165	0.0266±0.00239	0.0207±0.0180	0.0211±0.00183	0.0353±0.00848

All data are reported as Mean ± SD (n= 3)

Only one rat had concentrations > quantitation limit.

<LOQ = below limit of quantitation = quantitation limit; 0.0125 μg/g for tissues.