Table 1.
Body composition and cardiometabolic variables before and after weight loss.
| HIV− before | HIV− after | Percent difference |
HIV+ before |
HIV+ after | Percent difference |
|
|---|---|---|---|---|---|---|
| Body weight (kg) | 113±17 | 105±6 | −7.3±0.1* | 108±5 | 100±4 | −7.7±0.1* |
| BMI (kg/m2) | 39.9±2.2 | 36.9±1.9 | −7.1±1.0* | 39.1±1.6 | 36.3±1.5 | −7.2±0.8* |
| Fat-free mass (kg) | 55.7±3.0B | 54.8±2.9A, B | −1.7±1.0B | 51.1±2.0B | 48.9±1.9A, B | −4.4±0.7B |
| Appendicular fat-free mass (kg) |
25.5±.9 | 25.4±1.1* | −0.6±2.4 | 25.2±1.3 | 23.7±1.1*, B | −5.8±0.7B |
| Fat mass (% body weight) | 45.9±2.4 | 44.0±2.3 | −4.4±1.6* | 49.7±1.6 | 48.0±1.4 | −3.2±0.8* |
| Total abdominal adipose tissue (cm3) |
5052±574 | 4815±618 | −6.4±4.9* | 5227±428 | 4757±461* | −7.4±3.1* |
| Visceral adipose tissue (cm3) |
1139±187 | 1034±183 | −12±4* | 1164±140 | 997±137* | −14±4* |
| VAT:TAT ratio | 0.22±0.03 | 0.22±0.03 | −5.1±4.7* | 0.24±0.03 | 0.22±0.03* | −7.1±3.0* |
| IHTG content (%) | 7.5±2.4 | 5.4±1.5 | −16.8±43.8* | 4.6±1.7 | 2.2±1.0* | −26.3±18.6* |
| Systolic BP (mmHg) | 126±5 | 117±6 | −7±4* | 122±3 | 118±4 | −4±2* |
| Diastolic BP (mmHg) | 76±5 | 69±5 | −9±3* | 72±3 | 69±3 | −4±3* |
| Glucose (mg/dl) | 91.5±3.0 | 87.6±2.5 | −4.0±3.3 | 94.1±2.0 | 91.7±1.6 | −2.2±2.0 |
| Insulin (µU/L) | 18.3±3.3 | 8.8±2.6 A, B | −54.0±7.3B | 16.6±2.5 | 14.2±1.9B | −11.1±10.5B |
| C-peptide (ng/ml) | 3.2±0.5 | 2.2±0.4A, B | −28.2±9.4 | 2.8±0.3 | 2.7±0.2B | −3.9±6.6B |
| Leptin (µg/L) | 39.0±6.6 | 36.2±6.3 | −8.6±11.8* | 53.1±4.5 | 39.8±4.3 | −20.4±6.4* |
| Hemoglobin A1C (%) | 5.8±0.2 | 5.3±0.2 | −7.9±2.9 | 5.7±0.1 | 5.6±0.1 | −3.2±2.0 |
| FFA (µmol/ml) | 550±66 | 527±85 | −3.1±7.9 | 661±45 | 662±58 | −1.1±8.4 |
| LDL-C (mg/dl) | 111±14 | 100±7 | −9±5 | 103±10 | 101±12 | −1±4 |
| HDL-C (mg/dl) | 43±3 | 39±3A | −9±3* | 42±2 | 39±2 A | −7±3* |
| Triglyceride (mg/dl) | 128±28 | 92±28 | −17±15 | 112±18 | 119±22 | 12±12 |
Values are means±SE.
VAT:TAT, visceral adipose tissue (VAT) area as percent total abdominal adipose tissue (TAT) area; IHTG, intrahepatic triglyceride content; FFA, free-fatty acid; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol.
*
P<0.05 for main effect of time.
A
Value is different from corresponding value at baseline, P<0.05.
B
Value is different from corresponding value in other group, P<.0.05.