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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Curr Opin Struct Biol. 2016 Dec 4;42:75–82. doi: 10.1016/j.sbi.2016.11.016

Figure 2.

Figure 2

Structural insights into relation of FACT and DUB module binding to histones. All panels show relative position of DUB module (gray surface) on either H2A/H2B or H3/H4. (A) Docking of DUB module relative to a peptide derived from the C-terminus of Spt16 solved to 1.80 Å resolution (PDB ID: 4WNN). (B) The Spt16M domain from Chaetomium thermophilum fused to H2B solved to 2.35 Å resolution (PDB ID: 4KHA). (C) Structure of the human FACT mid-AID domain bound to an H3/H4 tetramer solved to 2.98 Å resolution (PDB ID: 4Z2M).

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