Model of the arrangement of SAGA subunits as determined by crosslinking mass spectrometry and electron microscopy subunit localization experiments. Sphere size is proportional to molecular weight. Binding sites of transcription factors are indicated, as determined by pull-down experiment and electron microscopy. Adapted from D. Setiaputra et al., 2015, Journal of Biological Chemistry, 290, p. 10057. © 2015 The American Society for Biochemistry and Molecular Biology with permission.