Skip to main content
. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: J Psychiatr Res. 2017 Feb 3;89:85–96. doi: 10.1016/j.jpsychires.2017.01.018

Fig. 4.

Fig. 4

Left: Left insula seed to voxelwise whole-brain connectivity result using the directional drug X diagnosis interaction contrast (Patient Placebo > Patient Nicotine) > (Control Placebo > Control Nicotine). A significant cluster was observed in the middle cingulate cortex. Statistical parametric map thresholded at p < 0.01, cluster size > 75 voxels purely for visualization purposes (significance threshold specified in methods). Images are presented in the neurologic convention (R on R). Abbreviations: MCC – middle cingulate cortex.

Right: Chart displaying the nature of the drug X diagnosis interaction. Cluster beta weight values represent the mean taken from the cluster. *p < 0.05 vs. control placebo (post-hoc test). **p < 0.05 vs. control nicotine. ***p < 0.05 vs. patient placebo.