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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: J Psychiatr Res. 2017 Feb 3;89:85–96. doi: 10.1016/j.jpsychires.2017.01.018

Table 3a.

Connectivity (beta weights) between the ACC seed and significant clusters drawn from whole-brain drug X diagnosis interaction contrasts. P values are drawn from post-hoc tests of simple main effects (see Methods) and are displayed to describe the nature of the interactions.

Brain Region Controls Patients
Placebo Nicotine p (nicotine vs. placebo) Placebo Nicotine p (patient vs. control placebo) p (nicotine vs. placebo)
SPL 0.11 (0.03) −0.0020 (0.03) 0.001 −0.07 (0.03) 0.07 (0.03) < 0.001 < 0.001
VLPFC 0.06 (0.03) −0.08 (0.03) 0.001 −0.07 (0.03) 0.08 (0.04) 0.004 < 0.001

Values in parentheses represent the standard error. Abbreviations: SPL – superior parietal lobule, VLPFC – ventrolateral prefrontal cortex.