Table 3b.
Connectivity (beta weights) between the left insula seed and the significant cluster drawn from whole-brain drug X diagnosis interaction contrasts. P values are drawn from post-hoc tests of simple main effects (see Methods) and are displayed to describe the nature of the interaction.
Brain Region | Controls | Patients | |||||
---|---|---|---|---|---|---|---|
Placebo | Nicotine | p (nicotine vs. placebo) | Placebo | Nicotine | p (patient vs. control placebo) | p (nicotine vs. placebo) | |
MCC | −0.09 (0.03) | 0.07 (0.02) | < 0.001 | 0.10 (0.03) | −0.14 (0.02) | < 0.001 | < 0.001 |
Values in parentheses represent the standard error. Abbreviations: MCC – middle cingulate cortex.