Table 1.
Rates of spontaneous unfolding and refolding of various protein domains. The first seven protein domains are taken from Table 1 of Jackson [19], which has original references to kinetics data. Data for the FNIII domains are from Shah et al **[20]. The C following the domain number indicates a Cys mutation introduced to measure kinetics by thiol exchange.
| Protein | Structure | PDB | ku s−1 | kf s−1 |
|---|---|---|---|---|
| Arc repressor | α/β | 1ARR | 1.5 | 10,600 |
| Monomeric λ repressor (λ6–85) | α | 1LMB | 30 | 4,900 |
| Villin 14T (headpiece) | α/β | 1VIK | 0.061 | 900 |
| CspA (B. subtilis) | ß-barrel | 1MEF | 4.2 | 200 |
| SH3 domain (PI3 kinase) | ß | 1PKS | 0.001 | 94 |
| Chymotrypsin inhib 2 | α/β | 1COA | 0.00018 | 48 |
| SH3 domain | ß | 1AEY | 0.045 | 8.1 |
| FN III-2C | ß | 2HA1 | 0.00027 | 4.8 |
| FN III-3C | ß | 2N1K | 0.0019 | 0.55 |
| FN III-6C | ß | 0.000013 | 0.14 | |
| FN III-7 | ß | 1FNF | 0.00007 | 1.4 |
| FN III-9C | ß | 1FNF | 0.00003 | - |
| FN III-11C | ß | 0.016 | 0.06 | |
| FN III-12C | ß | 1FNH | 0.00023 | 0.3 |
| Irisin | ß | 4LSD | 0.0021 | 1.9 |
| TNfn3C | ß | 1TEN | 0.006 | 0.72 |