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. Author manuscript; available in PMC: 2018 Apr 1.

Published in final edited form as: Clin Chem. 2017 Feb 7;63(4):870–879. doi: 10.1373/clinchem.2016.264515

Two methods for defining discordance between (a) nonHDLc and apoB and (b) nonHDLc and LDLp. (1) Discordance can be defined as one marker above and another below the median marker cut-points. (2) Discordance could also be defined based on residual differences from linear regression models estimating the difference between expected (based on the marker in comparison) and observed marker concentrations; here, those in the lowest residual quartile (purple circles; “apoB lower than expected based on nonHDLc”) are compared with those on the highest residual quartile (green circles; “apoB higher than expected”), using those in the intermediate two quartiles (red circles; “apoB close to excepted”) as the reference group. Median concentrations of nonHDLc, apoB, and LDLp are 154.4 mg/dL (4.0 mmol/L), 100.2 mg/dL (2.6 mmol/L), and 1,215.9 nmol/L, respectively.

Two methods for defining discordance between (a) nonHDLc and apoB and (b) nonHDLc and LDLp. (1) Discordance can be defined as one marker above and another below the median marker cut-points. (2) Discordance could also be defined based on residual differences from linear regression models estimating the difference between expected (based on the marker in comparison) and observed marker concentrations; here, those in the lowest residual quartile (purple circles; “apoB lower than expected based on nonHDLc”) are compared with those on the highest residual quartile (green circles; “apoB higher than expected”), using those in the intermediate two quartiles (red circles; “apoB close to excepted”) as the reference group. Median concentrations of nonHDLc, apoB, and LDLp are 154.4 mg/dL (4.0 mmol/L), 100.2 mg/dL (2.6 mmol/L), and 1,215.9 nmol/L, respectively.