Table 2.
Clinical (% or N [%]) and biochemical (median [25th, 75th percentiles]) variables among women with discordant or concordant values of nonHDL-c and LDLp.
| Discordant | Concordant | Discordant | |
|---|---|---|---|
| LDLp Lower Than Expected (Low Negative Residual) (n=6,884) | LDLp Close to Expected (Intermediate Residual) (n =13,766) | LDLp Higher Than Expected (High Positive Residual) (n=6,883) | |
| Age, years | 52.7 (48.8, 58.5) | 52.6 (48.8, 58.6) | 53.9 (49.6, 60.2) |
| Family history premature MI*, % | 13.7 | 14.0 | 16.0 |
| Smoker**, % | 47.5 | 47.7 | 50.4 |
| Post-menopausal, % | 53.3 | 52.4 | 59.2 |
| HRT use, % | 38.3 | 41.9 | 48.5 |
| Cardiometabolic Traits | |||
| Metabolic syndrome, % | 14.3 | 20.9 | 42.7 |
| BMI, kg/m2 | 24.0 (21.9, 27.1) | 24.6 (22.3, 28.2) | 26.5 (23.6, 30.2) |
| Hypertension, % | 21.3 | 23.0 | 33.2 |
| Diabetes, % | 2.0 | 2.0 | 4.8 |
| hsCRP, mg/L | 1.56 (0.62, 3.57) | 1.82 (0.73, 3.96) | 3.04 (1.40, 5.70) |
| Triglycerides, mg/dL | 110 (79, 160) | 110 (77, 158) | 154 (107, 217) |
| Lipid/Lipoprotein Profile | |||
| HDL-c, mg/dL | 59.5 (50.8, 69.8) | 52.5 (44.5, 62.3) | 43.9 (37.6, 51.7) |
| LDL-c, mg/dL | 124.0 (101.5, 149.6) | 116.7 (97.6, 137.6) | 129.1 (107.8, 151.5) |
| apoB, mg/dL | 93.6 (78.6, 113.4) | 96.3 (81.3, 115.2) | 118.8 (99.9, 136.9) |
| nonHDL-c, mg/dL | 157.1 (131.2, 187.9) | 147.3 (124.2, 172.2) | 167.5 (141.4, 193.8) |
| LDL size, nm | 21.5 (21.1, 21.8) | 21.2 (20.8, 21.5) | 20.7 (20.2, 21.1) |
| LDL-p, μmol/L | 965 (794, 1166) | 1175 (989, 1374) | 1635 (1419, 1880) |
| VLDL-p, μmol/L | 58.9 (44.2, 77.0) | 56.8 (40.4, 75.8) | 62.6 (45.1, 81.9) |
Abbreviations: CABG = coronary artery byupass grafting, hsCRP = high sensitivity C-reactive protein, HbA1c = glycated hemoglobin A1c, HRT = hormone replacement therapy, LDLp = low density lipoprotein particle concentration, MI = myocardial infarction, nm = nanometer, PTCA = percutaneous transluminal coronary angioplasty.
*
Family history premature MI <60 years of age.
**
Current or Former.
To convert mg/dL to mmol/L multiply by 0.02586 for cholesterol and by 0.01129 for triglycerides.