Table 3.

Hazard ratios (95% confidence intervals) from Cox proportional hazards models of incident CHD associated with discordant and concordant concentrations of nonHDL-c and apoB or LDL-p, based on residual differences.

Group	HR (95% CI) CHD* from Cox Proportional Hazards Regression
	apoB and nonHDLc
	Model 1**	Model 2**	Model 3**	Model 4**
Discordant High apoB	1.77 (1.56, 2.00)	1.67 (1.48, 1.89)	1.22 (1.07, 1.39)	1.14 (1.00, 1.30)†
Concordant	ref.	ref.	ref.	ref.
Discordant Low apoB	0.87 (0.74, 1.01)	0.88 (0.75, 1.03)	0.97 (0.83, 1.14)	0.93 (0.79, 1.10)
Group	LDLp and nonHDLc
	Model 1**	Model 2**	Model 3**	Model 4**
Discordant High LDLp	1.70 (1.50, 1.92)	1.57 (1.39, 1.78)	1.13 (0.99, 1.29)	1.06 (0.93, 1.21)
Concordant	ref.	ref.	ref.	ref.
Discordant Low LDLp	0.93 (0.80, 1.08)	0.93 (0.80, 1.09)	1.04 (0.89, 1.22)	0.98 (0.83, 1.15)

Abbreviations: CI = confidence interval; HR = hazard ratio.

^*Model 1 = randomization age-adjusted; Model 2 = Model 1 + randomized treatment assignment, hormone use, postmenopausal status, smoking (baseline history or not), and history of baseline hypertension; Model 3 = Model 2 + metabolic syndrome, diabetes mellitus (pre-randomization), body mass index, HDLc, triglycerides, high-sensitivity C-reactive protein (hsCRP), and parental history of premature myocardial infarction; Model 4 = Model 3 + baseline concentration of nonHDLc.

^**For apoB: P<0.001 for Models 1 and 2, P=0.002 for Model 3, P=0.012 for Model 4; for LDLp: P<0.001 for Models 1 and 2, P=0.23 for Model 3, P= 0.29 for Model 4.

^†P=0=0.046.