Table 2.
SNPs reaching genome-wide significance in the meta-analysis
| Fatty acid | Nearest Gene | SNP | CHR | Position | Coded allele/non-coded allele | CAF | NHAPC | MESA | Combined | I2 | Pheter | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||||||
| CAF | beta (SE) | P | CAF | beta (SE) | P | beta (SE) | P | |||||||||
| 14:0 | LMX1A | rs11589386 | 1 | 163270086 | C/T | 0.948 | 0.930 | 0.042 (0.013) | 1.52E-03 | 0.952 | 0.032 (0.006) | 4.78E-07 | 0.034 (0.006) | 5.08E-09 | 0 | 0.52 |
| 14:0 | AMPD3 | rs11042834 | 11 | 10458998 | A/G | 0.914 | 0.912 | 0.027 (0.012) | 2.46E-02 | 0.914 | 0.032 (0.006) | 3.92E-07 | 0.031 (0.006) | 4.33E-08 | 0 | 0.69 |
| 20:0 | CERS4 | rs17159388 | 19 | 8226555 | A/G | 0.191 | 0.191 | −0.011 (0.002) | 1.76E-10 | NA | NA | NA | −0.011 (0.002) | 1.76E-10 | NA | NA |
| Previously reported loci | ||||||||||||||||
| 16:0 | ALG14 | rs2391388 | 1 | 95258413 | C/A | 0.820 | 0.823 | 0.127 (0.086) | 0.140 | 0.816 | 0.137 (0.112) | 0.218 | 0.131 (0.069) | 0.058 | 0 | 0.94 |
| 18:0 | ALG14 | rs6675668 | 1 | 95288225 | T/G | 0.818 | 0.820 | −0.007 (0.058) | 0.905 | 0.809 | −0.113 (0.106) | 0.289 | −0.031 (0.051) | 0.543 | 0 | 0.38 |
| 18:0 | LPGAT1 | rs11119805 | 1 | 209984867 | A/T | 0.145 | 0.137 | −0.071 (0.062) | 0.248 | 0.173 | −0.002 (0.112) | 0.984 | −0.055 (0.054) | 0.310 | 0 | 0.59 |
| 18:0 | FADS1/2 | rs102275 | 11 | 61314379 | C/T | 0.406 | 0.358 | −0.159 (0.048) | 1.01E-03 | 0.596 | −0.316 (0.096) | 9.79E-04 | −0.191 (0.043) | 1.12E-05 | 0.53 | 0.15 |
SNP single nucleotide polymorphism, CHR chromosome, CAF coded allele frequency, NA not available, I2 I square of heterogeneity, P heter heterogeneity of effect sizes between NHAPC and MESA studies