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. Author manuscript; available in PMC: 2018 May 15.
Published in final edited form as: Gene. 2016 Sep 30;612:25–28. doi: 10.1016/j.gene.2016.09.046

Fig. 1. Schematic illustration of a common mechanism of alcohol-associated cancers.

Fig. 1

Alcohol increases Brf1 expression through JNK1 and c-Jun pathway, which in turn upregulates Pol III gene transcription to promote cell transformation and tumor development caused by alcohol.