Table 3.

Annualized rates of change in clinical scores

	PPAOS non- progressors	PPAOS progressors	Z*	P value
MMSE	0.0 (−0.5,0)	−0.2 (−0.9,0.1)	−0.1	0.94
CDR-SB	0 (0,1.0)	0.1 (0,0.5)	0.0	1.00
FAB	−0.6 (−1.1,0)	−1.1 (−1.2,−0.9)	−1.2	0.24
Limb apraxia	−1.5 (−2.8,0)	−2.4 (−3.6,−1.2)	−0.8	0.44
UPDRS III	6.9 (1.6,10.7)	4.1 (1.2,7.5)	−0.5	0.59
NPI	0.2 (−0.7,0.5)	0 (−0.6,0.7)	0.2	0.79
AVLT delayed recall	0 (−0.8,0.4)	0 (−0.3,0.6)	0.2	0.85
DKEFS card sort	0.5 (−1.1,1.7)	0 (−1.0,0.4)	−0.8	0.45
VOSP letters	0 (0,0)	0 (0,0.3)	1.4	0.16
Token Test	0 (−0.8,0)	−1.1 (−2.1,−0.8)	−2.1	0.03
WAB-AQ	−1.2 (−1.4,−0.2)	−4.9 (−6.1,−2.5)	−2.1	0.03
WAB-fluency	0 (−0.4,0)	−1.7 (−2.1,−0.8)	−2.3	0.02
WAB-info content	0 (0,0)	0 (−0.4,0)	−1.0	0.31
WAB-AV comp	0 (0,0)	0 (−0.1,0)	−1.7	0.10
BNT	0 (−0.2,0)	−0.4 (−0.8,0)	−1.0	0.30
MSD	−0.7 (−1.2,−0.4)	−0.8 (−1.2,−0.6)	−0.2	0.85
AOS severity	0.5 (0.4,0.7)	0.5 (0.4,0.6)	−0.0	0.97
Letter fluency	−2.1 (−4.0,−0.1)	−3.5 (−4.9,−0.3)	−0.3	0.77
Animal fluency	−1.2 (−2.0,0.0)	−1.8 (−3.1,−1.0)	−1.0	0.30
Dysarthria severity	0.3 (0,0.4)	0.1 (0,0.4)	−0.6	0.56

Data shown as median (inter-quartile range); All rates are expressed as points change per year (rate=repeat-baseline/interval). PPAOS = primary progressive apraxia of speech; MMSE = Mini-Mental State Examination; CDR-SB = Clinical Dementia Rating Sum of Boxes; FAB = Frontal Assessment Battery; UPDRS = Movement Disorders Society Sponsored revision of the Unified Parkinson’s Disease Rating Scale; NPI = Neuropsychiatric Inventory; AVLT = Auditory Verbal Learning Test; DKEFS = Delis-Kaplan Executive Function System; VOSP = Visual Object and Space Perception Battery; WAB = Western Aphasia Battery; WAB-AQ=WAB Aphasia Quotient; AV comp = auditory verbal comprehension; BNT = Boston Naming Test; AOS = apraxia of speech; MSD = Motor Speech Disorders severity scale

^*Z statistic reported from the large-sample approximation/tie correction of the Mann-Whitney U statistic/Wilcoxon rank sum statistic