Table 3.
Top 106 epitopes in terms of T cell response magnitude
| Cluster # | Protein | Start position | Sequence | % Donors responding | % of average SFC/donor |
|---|---|---|---|---|---|
| 8 | Novel | 266 | KDSQYLQHFNNAIKQ | 15% | 0.41% |
| 8 | Novel | 271 | LQHFNNAIKQLNTED | 10% | 0.05% |
| 10 | Novel | 771 | YDDIDYVFVRGGSII | 30% | 0.51% |
| 10 | Novel | 596 | ILSDWSSMRWTIPSI | 30% | 0.12% |
| 10 | Novel | 471 | NATEYWMDMFAEYHK | 25% | 0.78% |
| 10 | Novel | 886 | PRIIRFNYDEQTNIL | 25% | 0.55% |
| 10 | Novel | 591 | HWNGDILSDWSSMRW | 25% | 0.31% |
| 10 | Novel | 146 | DQVLRLKFIDANQKR | 20% | 0.77% |
| 10 | Novel | 201 | QSIFDINLAYMVYSD | 20% | 0.24% |
| 10 | Novel | 676 | SSLQYRYRFLAHLYT | 20% | 0.13% |
| 10 | Novel | 865 | INILGVPKLPTSFKL | 20% | 0.08% |
| 10 | Novel | 671 | IRAARSSLQYRYRFL | 20% | 0.07% |
| 10 | Novel | 643 | AFYSFVRNHNTDNAI | 20% | 0.05% |
| 10 | Novel | 356 | FTNLNTTYTRNRAVG | 15% | 0.32% |
| 10 | Novel | 361 | TTYTRNRAVGIPMDV | 15% | 0.27% |
| 10 | Novel | 859 | TQNINFINILGVPKL | 15% | 0.25% |
| 10 | Novel | 881 | GKPYYQFIYTTNNML | 15% | 0.15% |
| 10 | Novel | 636 | LCIRWYQLGAFYSFA | 15% | 0.14% |
| 10 | Novel | 641 | YQLGAFYSFARNHND | 15% | 0.12% |
| 10 | Novel | 666 | LGESVIRAARSSLQY | 15% | 0.10% |
| 10 | Novel | 481 | AEYHKTIAFDGAWLD | 15% | 0.08% |
| 10 | Novel | 681 | RYRFLAHLYTLFYHV | 10% | 0.55% |
| 16 | Der 4 | 131 | AGVRIYVDIVLNHMT | 25% | 1.18% |
| 17 | Novel | 266 | TFLVYADFLSYKSGV | 20% | 0.46% |
| 17 | Novel | 236 | DRYFGQSAYHVHSNV | 20% | 0.20% |
| 17 | Novel | 241 | KSAYRVSSIVSQIQH | 15% | 0.20% |
| 17 | Novel | 281 | YKRHSVQALGGHAIK | 15% | 0.13% |
| 23 | Novel | 76 | YDIKYSYNVPAVLPN | 25% | 0.44% |
| 23 | Novel | 36 | DSEHLKLIISADVNG | 20% | 0.76% |
| 23 | Novel | 86 | AVLPNIKGTLTAKVI | 20% | 0.64% |
| 29 | Der 20 | 273 | IEKKLPFSRDDRLGF | 25% | 0.85% |
| 29 | Der 20 | 119 | VDPKNEYVISTRVRC | 20% | 0.60% |
| 29 | Der 20 | 124 | EYVISTRVRCGRSLK | 15% | 0.68% |
| 29 | Der 20 | 258 | DLKQVFSRLINGVNH | 15% | 0.25% |
| 29 | Der 20 | 253 | MQKGGDLKQVFSRLI | 15% | 0.21% |
| 31 | Novel | 46 | LKPEFLKVNPFHKIP | 20% | 0.13% |
| 31 | Novel | 56 | FHKIPTFVDTDGFTI | 15% | 0.40% |
| 31 | Novel | 166 | DIAMYFSCNTMEIYS | 15% | 0.07% |
| 33 | Novel | 286 | KHPWIIVMGHRPLYC | 20% | 0.32% |
| 33 | Novel | 351 | EHFYARLFPIYKYKM | 15% | 0.50% |
| 38 | Der 22 | 58 | NQLRISFVANENTGN | 15% | 0.60% |
| 39 | Der 8 | 76 | VKITQSMAILRYLAR | 15% | 0.21% |
| 40 | Novel | 386 | IAVGFEVYKDFMTYR | 20% | 0.56% |
| 40 | Novel | 36 | GLWLFEESTPINDRT | 20% | 0.50% |
| 42 | Der 3 | 29 | ILDEYWILTAAHCVN | 50% | 0.80% |
| 42 | Der 3 | 94 | PMTLDQTNAKPVPLP | 40% | 0.81% |
| 42 | Der 3 | 44 | GQSAKKLSIRYNTLK | 25% | 2.04% |
| 42 | Der 3 | 49 | KLSIRYNTLKHASGG | 25% | 1.46% |
| 42 | Der 3 | 79 | SYQIDNDIALIKLKS | 25% | 0.53% |
| 42 | Der 3 | 89 | IKLKTPMTLDQTNAK | 20% | 0.47% |
| 42 | Der 3 | 14 | YQISLQSSSHFCGGS | 20% | 0.07% |
| 42 | Der 3 | 64 | EKISVAKIFAHEKYD | 15% | 0.27% |
| 42 | Der 3 | 84 | NDVALIKLKTPMTLD | 15% | 0.25% |
| 43 | Novel | 41 | AHCVAGQTASKLSIR | 15% | 0.27% |
| 43 | Novel | 46 | GQSAKKLSIRYNTLK | 15% | 0.20% |
| 53 | Novel | 261 | YTMHYYLNNGATRDK | 25% | 0.61% |
| 53 | Der 15 | 91 | SWEKRGYERFNNLRL | 20% | 0.10% |
| 53 | Der 15 | 256 | YFNVNYTMHYYLNNG | 15% | 0.15% |
| 53 | Der 15 | 96 | GYERFNNLRLKNPEL | 15% | 0.09% |
| 53 | Der 15 | 41 | GTWSVYHKVDPYTIE | 15% | 0.08% |
| 53 | Der 15 | 271 | ATRDKLVMGVPFYGR | 15% | 0.06% |
| 61 | Novel | 106 | EQYISGVILFDETVY | 20% | 1.13% |
| 61 | Novel | 36 | IIMAKFNYLPVDVQE | 15% | 0.13% |
| 64 | Novel | 196 | PPKPELLVIDTELGR | 30% | 0.79% |
| 64 | Novel | 201 | LLVIDTELGRLGMQI | 20% | 0.19% |
| 64 | Novel | 211 | LGMQICFDMIFKTPG | 20% | 0.10% |
| 72 | Der 9 | 103 | STTIDYDVATLILSE | 30% | 0.62% |
| 72 | Der 9 | 135 | YDVATLILSQPFTPS | 25% | 1.73% |
| 72 | Der 9 | 140 | LILSQPFTPSANADI | 25% | 1.22% |
| 72 | Der 9 | 73 | SYFKIRYNTLDRTNG | 25% | 0.75% |
| 72 | Der 9 | 93 | SKIYRHSLYSSTTID | 25% | 0.24% |
| 72 | Der 9 | 173 | SNIWGSVNAITNRML | 20% | 0.68% |
| 72 | Der 9 | 33 | DAIYQIALLRKDSFT | 20% | 0.64% |
| 72 | Der 9 | 178 | SVNAITNRMLCAHSK | 20% | 0.63% |
| 72 | Der 9 | 1 | MKFMILFALIAIGTS | 20% | 0.45% |
| 72 | Der 9 | 48 | CGGSLISSRTVLTAA | 15% | 3.94% |
| 72 | Der 9 | 185 | ILQIASVTKMSRTKC | 15% | 0.69% |
| 72 | Der 9 | 65 | IALFRKDSFTCGGSL | 15% | 0.43% |
| 72 | Der 9 | 255 | PTIYSNVANLRNWII | 15% | 0.36% |
| 72 | Der 9 | 53 | ISSRTVLTAAHCVFG | 15% | 0.18% |
| 72 | Der 9 | 125 | HNLYSSSPIDYDVAT | 15% | 0.11% |
| 74 | Der 6 | 136 | TIQNDISLLILSKPV | 35% | 1.27% |
| 74 | Der 6 | 66 | SLLKDYLIMKSHMCG | 35% | 0.48% |
| 74 | Der 6 | 61 | APFQISLLKDYLIMK | 30% | 1.23% |
| 74 | Der 6 | 235 | GPLVSANRKLTGIVS | 30% | 1.21% |
| 74 | Der 6 | 131 | SYDPDTIQNDISLLI | 30% | 0.66% |
| 74 | Der 6 | 71 | YLIMKSHMCGGSLIS | 30% | 0.32% |
| 74 | Der 6 | 11 | IVITVTVDARFPRSL | 20% | 0.17% |
| 74 | Der 6 | 256 | PPGEYMSVFTRPKYY | 15% | 0.74% |
| 74 | Der 6 | 206 | EKWGSINAIHPGMIC | 15% | 0.15% |
| 74 | Der 6 | 15 | NIWLWSINNSHLKTT | 15% | 0.09% |
| 75 | Novel | 69 | SVYQGTHKVLARVAS | 30% | 0.79% |
| 75 | Novel | 19 | YCNGAAIVSAARSQI | 30% | 0.70% |
| 75 | Novel | 24 | AIVSAARSQIGVPYS | 25% | 1.26% |
| 75 | Novel | 102 | GDLVFFGNPIHHVGI | 15% | 0.83% |
| 75 | Novel | 1 | TIMKFFFTLALFCTL | 15% | 0.08% |
| 77 | Der 5 | 26 | YQNEFDFLLMQRIHE | 15% | 0.76% |
| 77 | Der 5 | 101 | FERYNVEIALKSNEI | 15% | 0.55% |
| 99 | Novel | 91 | VSEFRRMNGLIASKG | 15% | 0.25% |
| 102 | Novel | 186 | YVPWTTVESRTVDVN | 20% | 0.18% |
| 102 | Novel | 166 | TGQKGFELIKVMARK | 15% | 2.09% |
| 102 | Novel | 81 | EYVDIDLVPFGNAHI | 15% | 1.44% |
| 102 | Novel | 171 | FELIKVMARKTPRHN | 15% | 1.09% |
| 103 | Novel | 106 | GMIRRMVNLRTYNPH | 20% | 0.79% |
| 103 | Novel | 101 | LQWGHGMIRRMVNLR | 20% | 0.78% |
| 103 | Novel | 111 | MVNLRTYNPHLTTMI | 20% | 0.47% |