Figure 1.

The Structural Basis for ICAM-1 Binding by Group A PfEMP1s

(A) Front and side views of the PF11_0521 DBLβ_D4 domain (green) bound to ICAM-1^D1D2 (D1, light blue; D2, dark blue). Dashed boxes highlight three sites that make direct contact with ICAM-1.

(B) Back view of PF11_0521 DBLβ_D4 domain (green) bound to ICAM-1^D1D2. Dashed lines represent residues not visible in the electron density map with the disordered regions near site 3 (orange) of the ICAM-1-binding site highlighted.

(C) Three distinct sites in the PF11_0521 DBLβ_D4 domain directly interact with ICAM-1 with residues that mediate this interaction indicated.

See also Figures S1 and S2 and Tables S1 and S2.