Figure 7.

Dual-Binding PfEMP1s Correlate with CM

Percentages of specific var gene transcripts in infected erythrocytes from 45 hospitalized Tanzanian children.

(A) Percentage of var gene transcripts encoding PfEMP1s predicted to bind both ICAM-1 and EPCR.

(B) Percentage of transcripts that encode PfEMP1 predicted to bind EPCR and not containing the ICAM-1-binding motif. CM, cerebral malaria; SA, severe anemia; OM, children without the signs of severity found in the other groups.

See also Table S5.