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. 2016 Dec 28;595(7):2301–2317. doi: 10.1113/JP273191

Figure 5. Experimental confirmation of greatly reduced I Ks predicted by model adjustments.

Figure 5

A, in the original model, 80% reduction in G Ks dramatically prolongs APD. B, the adjusted model shows only a small (10%) prolongation in APD with 80% reduction in GKs. C, in experimental measurements (n = 4), 10 μm chromanol 293B (which should block I Ks by approximately 80%) caused minimal APD prolongation. D, quantification of percentage change in APD with 10 μm chromanol 293B for each condition shows better agreement between adjusted model and experiment.