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. 2016 Dec 26;595(7):2339–2364. doi: 10.1113/JP273255

Figure 5. The role of Kir2.1 function in mesenteric artery dilatation is endothelial dependent.

Figure 5

A, representative sodium nitroprusside (SNP)‐induced vasodilatation of pre‐constricted denuded mesenteric arteries. SNP was perfused extravascularly. The endothelium was mechanically denuded by forcing 5 ml of air through the vessel lumen. B, average dilatations as a function of SNP dose (n = 5 per group). C, average dilatations of intact and denuded vessels in response to ACh (n = 4 per group). D, representative K+‐induced vasodilatation of pre‐constricted denuded mesenteric arteries from WT and Kir2.1+/− mice. E, average dilatations of arteries from WT and Kir2.1+/− mice as a function of K+ dose (KCl) (n = 5 arteries per condition). F, average dilatations at 20 mm KCl. ET‐1, endothelin‐1; PAP, papaverine (added at the end of experiments to test the vessels’ maximal dilatation).