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. 2016 Dec 26;595(7):2339–2364. doi: 10.1113/JP273255

Figure 13. Kir and SK channels contribute to flow‐induced vasodilatation of human microvessels.

Figure 13

A, average flow‐induced dilatations of pre‐constricted subcutaneous vessels harvested from human lower abdominal adipose tissue with and without 20 nm apamin (AP), 300 μm Ba2+, or both, as a function of pressure gradient. Vessel diameters are normalized to diameters stabilized at 60 cmH2O. Intralumenal pressure is maintained as 60 cmH2O. Apamin and Ba2+ perfused extravascularly and maintained during the experiments. Papaverine (100 μm) is added at Δ100 cmH2O at the end of the experiment to verify the maximal dilatation of arteries (n = 9 vessels per condition, * P < 0.05). B, maximal dilatation at Δ100 cmH2O pressure gradient for the same experimental conditions.