Table 3.
Results of the pooled sensitivity, specificity and AUC from the literature search for diagnostic ability, predictive ability of recurrence and metastases for CEA, CA19-9 and CA125, with respect to colorectal cancer
| Tumor marker | Diagnosis | Diagnosis of recurrence | Diagnosis of metastases | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Sensitivity | Specificity | AUC | Sensitivity | Specificity | AUC | Sensitivity | Specificity | AUC | |
| CEA | 0.533 (0.502–0.563) | 0.864 (0.848–0.881) | 0.704 | 0.550 (0.527–0.571) | 0.808 (0.796–0.820) | 0.779 | 0.632 (0.600–0.664) | 0.771 (0.753–0.789) | 0.771 |
| CA19-9 | 0.471 (0.436–0.506) | 0.924 (0.907–0.939) | 0.674 | 0.325 (0.289–0.363) | 0.751 (0.721–0.789 | 0.549 | 0.000* | 0.000* | 0.000* |
| CA125 | 0.198 (0.148–0.257) | 0.993 (0.977–0.999) | 0.993 | 0.245 (0.198–0.287) | 0.639 (0.593–0.683) | 0.550 | 0.000* | 0.000* | 0.000* |
Values in parentheses represent 95% confidence intervals
AUC area under the curve, CEA carcinoembryonic antigen, CA cancer antigen
* Insufficient data available