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Mean percentage change in BV (measured with SIENA) from baseline in the 2-year FREEDOMS trial, in subgroups of patients with and without gadolinium-enhancing lesions at baseline [35]. BV brain volume, Gd+ gadolinium-enhancing, SIENA Structural Image Evaluation, using Normalization, of Atrophy; *p < 0.05, **p < 0.01, ***p < 0.001 versus placebo
