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. 2016 Sep 20;27(5):1901–1911. doi: 10.1007/s00330-016-4565-2

Table 2.

Area under the curve from the ROC analysis of pathologic complete response prediction using different MRI measures

AUC Baseline After 2 cycles After 3-4 cycles After 5 cycles
Size measure: number of lesions in the analysis (pCR) 41 (7) 13 (3) 18 (3) 36 (6)
Lesion size
 Maximal diameter 0.563 0.821
 2D diameter 0.580 0.667 0.889 0.761
 3D diameter 0.626 0.633 0.933 0.761
 3Dseg 0.527 0.600 0.889 0.788
Size ratio (TP/BS)
 2D diameter 0.833 0.889 0.817
 3D diameter 0.833 0.933 0.811
 3Dseg 0.700 0.867 0.727
ADC measure: number of lesions in the analysis (pCR) 42 (7) 14 (3) 19 (3) 34 (6)
2D ADC values
 Mean 0.637 0.667a 0.542 0.800
3D ADC values
 Mean 0.633 0.697a 0.500 0.743
 Median 0.635 0.788a 0.563
 15th percentile 0.669 0.697a 0.583
 25th percentile 0.673 0.636a 0.521
 75th percentile 0.527 0.697a 0.500
 90th percentile 0.531 0.636a 0.521
Δ 3D ADC (TP-BS)
 Mean 0.606 0.729 0.577
 Median 0.788 0.750
 15th percentile 0.667 0.771
 25th percentile 0.788 0.750
 75th percentile 0.515 0.646
 90th percentile 0.576 0.729

Note: pCR pathologic complete response, Δ difference of, 3Dseg 3D segmented tumour size, TP time-point, BS baseline; the numbers in parenthesis correspond to the number of pCR patients in that group

ain ROC analysis, using real ADC values, smaller values were considered positive for pCR prediction in BS, after three to four cycles and after five to eight cycles; however, higher values were considered positive for pCR prediction in data measured after two cycles