Figure 1.

Representative images of H&E stained (A) and Masson's trichrome (B) lung sections obtained from mice of 4 study groups. Mice were intratracheally infused with either PBS or a single sublethal dose of bleomycin (3 mg/kg). Mice also received daily treatment with paeonol (10 mg/kg; Pae) or saline (Sal.) by gastric gavage for 21 days. Lung tissues were obtained 21 days after bleomycin treatment. The magnification is 200X for each panel. Note that bleomycin resulted in extensive infiltration of inflammatory cells (A) and collagen deposition, as indicated by the blue color (B). These signs of pulmonary inflammation and fibrosis were markedly alleviated by paeonol treatment.