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. 2017 Mar 31;8:193. doi: 10.3389/fphys.2017.00193

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Copyright © 2017 Liu, Lin, Ko, Perng, Lee and Kou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Treatment with paeonol (Pae) inhibits TGF-β1-induced increases in expression of α-smooth muscle actin (α-SMA) and type 1α1 collagen (COL1A1) in human lung fibroblasts. In (A), stimulatory effects of different concentrations of TGF-β1 (0–5 ng/ml) on α-SMA were studied. In (B,C), the suppressive effects of Pae (0–0.4 mM) on TGF-β1 (5 ng/ml)-induced α-SMA and COL1A1 were studied. Protein samples were harvested 24 h after treatments and data were measured by Western blot analysis. Data in each group are mean ± SEM from 4 independent experiments. ^*p < 0.05 vs. the control group; ^#p < 0.05 vs. the TGF-β1 group without Pae treatment.