Table 1.
Overlap of Exosome Functional Gene Set with PerturbDB and HTT Interactome.
| Exosome function | Dme gene | Gene symbol | Gene name | PerturbDB | HTT Interactome | |
|---|---|---|---|---|---|---|
| 1 | Release | Arf79f | ARF1|3 | ADP-ribosylation factor class I | Yes | |
| 2 | ARF4|5 | ADP-ribosylation factor class II | Aggreg | |||
| 3 | Release | Vha68-2 | ATP6V1A | ATPase, H+ transporting | Aggreg | Yes |
| 4 | Release | Vha55 | ATP6V1B2 | ATPase, H+ transporting | Yes | |
| 5 | ATP6V1B1 | ATPase, H+ transporting | Aggreg | |||
| 6 | Release | Vha26 | ATP6V1E1 | ATPase, H+ transporting | Aggreg | Yes |
| 7 | Release | VhaSFD | ATP6V1H | ATPase, H+ transporting | Aggreg | Yes |
| 8 | Release | Myo5 | MYO5A|B | Myosin V | Yes | |
| 9 | Release | Rab11 | RAB11A|B | Rab 11 | HD Fly; Aggreg | Yes |
| 10 | Release | Syx1a | STX1A | Syntaxin 1A | HD Fly | Yes |
| 11 | Uptake | Chc | CLTC | Clathrin, heavy chain | HD Fly | Yes |
| 12 | Uptake | Shi | DNM1 | Dynamin 1 | HD Fly | Yes |
| 13 | DNM2 | Dynamin 2 | Aggreg; Cell Tox | Yes | ||
| 14 | Release | YWHAB | 14-3-3 family | HD Fly | Yes | |
| 15 | YWHAE | 14-3-3 family | HD Fly; Aggreg | Yes | ||
| 16 | YWHAZ | 14-3-3 family | HD Fly; Aggreg | Yes | ||
| 17 | YWHAG | 14-3-3 family | HD Fly | Yes | ||
| 18 | YWHAH | 14-3-3 family | Yes | |||
| 19 | YWHAQ | 14-3-3 family | Yes | |||
| 20 | MVBs | VPS28 | ESCRT-I Complex | HD Fly | ||
| 21 | VPS25 | ESCRT-II Complex | HD Fly | |||
| 22 | CHMP3 | ESCRT-III Complex | Aggreg | |||
| 23 | CHMP4A | ESCRT-III Complex | Aggreg | |||
| 24 | CHMP4B | ESCRT-III Complex | HD Fly; Aggreg | Yes | ||
| 25 | CHMP5 | ESCRT-IV Complex | Yes | |||
| 26 | VPS4A | ESCRT-IV Complex | Aggreg; Cell Tox | |||
| 27 | VPS4B | ESCRT-IV Complex | Aggreg |
Aggreg, mammalian mHTT or C. elegans in vivo pure polyQ aggregation; HD Fly, Drosophila in vivo phenotypes platform; Cell Tox, Mammalian cell culture toxicity platform; MVBs, multi-vesicular bodies.