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Plackett–Burman experimental design with 12 runs with corresponding mevastatin production.
| S. no | A | B | C | D | E | F | G | H | Mevastatin (mg L−1) |
|---|---|---|---|---|---|---|---|---|---|
| 1 | + | + | − | + | + | + | − | − | 100 |
| 2 | + | − | + | + | + | − | − | − | 95.6 |
| 3 | − | + | + | + | − | − | − | + | 170.4 |
| 4 | + | + | + | − | − | − | + | − | 148 |
| 5 | + | + | − | − | − | + | − | + | 139.2 |
| 6 | + | − | − | − | + | − | + | + | 95.6 |
| 7 | − | − | − | + | − | + | + | − | 146 |
| 8 | − | − | + | − | + | + | − | + | 136.5 |
| 9 | − | + | − | + | + | − | + | + | 112.4 |
| 10 | + | − | + | + | − | + | + | + | 108.4 |
| 11 | − | + | + | − | + | + | + | − | 0 |
| 12 | − | − | − | − | − | − | − | − | 0 |
