Fig. 2.

TA inhibits expression of HDAC6 and enhances acetylation histone H3. The kidney tissue lysates were subjected to immunoblot analysis with specific antibodies against acetylated histone H3 (A) and β-actin and HDAC6 (C). Expression level of acetyl-H3 (B) and HDAC6 (D) was quantified by densitometry and normalized with β-actin. E: photomicrographs illustrating HDAC6 immunofluorescence staining of kidney tissue collected at day 2 after GL administration with/without TA. Data are represented as the means ± SE (n = 6). Means with different superscript letters are significantly different from one another (P < 0.05).