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Mechanisms of HDAC6 inhibition-elicited attenuation of rhabdomyolysis-induced AKI. HDAC6 inhibition protects against rhabdomyolysis-induced acute kidney injury through at least 2 mechanisms: inhibition of NF-κB signaling pathway and subsequent production of multiple inflammatory cytokines/chemokines and reduction of oxidative stress by decreasing MDA expression levels and increasing SOD activity.
