Fig. 8.

Effect of systemic IL-17 blockade on AKI-induced renal fibrosis. A: representative images through the renal outer medulla are shown for picosirius red-stained sections of kidneys from vehicle-treated rats and IL-17Rc-treated rats. Increase in interstitial fibrosis is apparent in vehicle-treated rats post-I/R, which was reduced by IL-17Rc treatment. Magnification is shown. B: quantification of interstitial fibrosis area based on picosirius red staining. Data are means ± SE. *P < 0.05, IL-17Rc vs. vehicle using Student’s t-test (n = 3-5 animals/group).