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. 2017 Mar 1;10(3):323–336. doi: 10.1242/dmm.026682

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Experimental protocol. Dotted lines indicate the periods where mice remained undisturbed in their home cages. (A) The -Behav mice were exposed to chronic cocaine (COC-Behav) or vehicle (VEH-Behav) treatment and were behaviorally assessed 44 days after treatment. All the -Behav mice received cocaine when tested in the CPP apparatus. (B) The -Control mice underwent a cocaine (COC-Control) or vehicle (VEH-Control) treatment similar to the -Behav groups but remained undisturbed in their home cage (no behavioral testing). (C) The -Basal mice received the chronic cocaine (COC-Basal) or vehicle (VEH-Basal) treatment and remained in undisturbed in their home-cage with no further cocaine exposure. CPP, conditioned place preference; Hab., habituation session.