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. 2017 Mar 1;10(3):323–336. doi: 10.1242/dmm.026682

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — Effect of chronic cocaine withdrawal on adult hippocampal neurogenesis. Vehicle- and cocaine-treated mice (VEH- and COC-) showed no differences in AHN-related parameters when evaluated in control conditions (A-E; Fig. S1). However, after behavioral training, the COC-Behav mice showed a reduced PCNA expression in the infragranular blade (A,D) and a reduced percentage of mature-like ‘Type 2’ DCX⁺ neurons (C,E) in this region. Results are represented as means±s.e.m. Arrowhead in D indicates positive cell. In E, the white arrowheads indicate DCX⁺ ‘Type 2’ mature-like neurons, whereas black arrowheads indicate DCX⁺ immature-like ‘Type 1’ neurons. Scale bars in D also apply to E. Post hoc LSD test: *P<0.05 for VEH versus COC.